HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 6-(2-Thienyl)pyridine-3-carbonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 6-(Thiophen-2-Yl)Pyridine-3-Carboxylic Acid | HCID 15411144 | — |
| Product | 6-(2-Thienyl)pyridine-3-carbonyl chloride | HCID 17879033 | — |
Reaction Steps
A mixture of 1.8 g of 6-(2-thienyl)pyridine-3-carboxylic acid in 50 ml of thionyl chloride is refluxed under dry conditions for 1 hour. The reaction mixture is evaporated to dryness and evaporated again from 50 ml of carbon tetrachloride to a residue. The residue is dissolved in 60 ml of methylene chloride and used further reactions.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05521173 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-91e25bf160764e81b0ace79c715a5053 |
| Source note | uspto-grants-1996_05 |