Dimethylformamide → HCID 67771654, compound

Participants

Reaction Steps

A.2. Reaction of methyl 5-amino-2-(4-chlorophenoxy)-benzoate with maleic anhydride in a solvent such as methylene chloride or dimethylformamide in the presence of pyridine or 4-dimethylaminopyridine gives (Z)-but-2-enedicarboxylic acid 3-carbomethoxy-4-(4-chloro-phenoxy)-phenylamide which is converted by saponification with aqueous sodium hydroxide or potassium hydroxide in water and a second solvent such as methanol, ethanol or acetonitrile into (Z)-but-2-enedicarboxylic acid 3-carboxy-4-(4-chloro-phenoxy)-phenylamide, melting point: 224°-226° C.

Provenance & Evidence