Water → 2-(1-Propenyloxymethyl)morpholine

2-(Allyloxymethyl)morpholine (39.5 g, 0.25 mol) was dissolved in 1,4-dioxane (500 ml), and potassium tert-butoxide (28.2 g, 0.25 mol) was added to the solution at room temperature, followed by heating under reflux for 3 hours. After completion of the reaction, water was added to the reaction mixture at room temperature, and the reaction mixture was extracted with chloroform (3×1000 ml). The extract was washed with a saturated aqueous solution of sodium chloride (1000 ml) and dried over magnesium sulfate. The solvent was evaporated to give crude 2-(1-propenyloxymethyl)morpholine (40.0 g) as a pale yellow oily substance.

1. temperatureby heating
2. temperatureunder reflux for 3 hours
3. additionwas added to the reaction mixture at room temperature
4. extractionthe reaction mixture was extracted with chloroform (3×1000 ml)
5. washThe extract was washed with a saturated aqueous solution of sodium chloride (1000 ml)
6. dry with materialdried over magnesium sulfate
7. customThe solvent was evaporated

ORD record

ord-433a069850eb48378f3434745611c334

Source dataset

uspto-grants-1996_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05521180