4-Fluoro-7-hydroxy-2,3-dihydro-1H-inden-1-one → 7-Fluoro-2,3-dihydro-1H-inden-4-ol

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Reaction Steps

4-Fluoro-7-hydroxy-1-indanone (1.0 g) was dissolved in acetic acid (15 ml) and the solution was stirred with 10% palladium-on-carbon (0.5 g) in a hydrogen atmosphere at atmospheric pressure for 12 hours. The catalyst used was removed by filtration using Celite, and the filtrate was concentrated to give 7-fluoro-4-indanol (0.783 g).

Provenance & Evidence