Sodium Hydroxide → HCID 178439921, compound

HRID 440840Notes

Reaction equation

HRID 440840 reaction equation
[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([O:24]C)=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:26]=[C:27]([NH:31][C:32]([NH:36][CH3:37])=[N:33][C:34]#[N:35])[CH:28]=[C:29]([CH3:30])[C:6]=2[N:5]=1)[CH2:2][CH3:3].[OH-].[Na+]>C(O)C>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([OH:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:26]=[C:27]([NH:31][C:32]([NH:36][CH3:37])=[N:33][C:34]#[N:35])[CH:28]=[C:29]([CH3:30])[C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178439922HCID 178439922, compound

Product 1

HCID 178439921HCID 178439921, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 1d from methyl 4'-[[2-n-propyl-4-methyl-6-(2-cyano-3-methyl-guanidino)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate and 2N sodium hydroxide solution in ethanol.

Sources & evidence

ORD record
ord-2f4ff3c8ca854590b4722908861174c2
Source dataset
uspto-grants-1996_05
Patent number
US05521177

Reaction notes

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