Sodium Hydroxide → HCID 178439928, compound

HRID 440854Notes

Reaction equation

HRID 440854 reaction equation
[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([O:24]C)=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:26]=[C:27]([NH:31][C:32]([N:36]([CH2:38][CH2:39][OH:40])[CH3:37])=[N:33][C:34]#[N:35])[CH:28]=[C:29]([CH3:30])[C:6]=2[N:5]=1)[CH2:2][CH3:3].[OH-].[Na+]>C(O)C>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([OH:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:26]=[C:27]([NH:31][C:32]([N:36]([CH2:38][CH2:39][OH:40])[CH3:37])=[N:33][C:34]#[N:35])[CH:28]=[C:29]([CH3:30])[C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 178439929HCID 178439929, compound

Product 1

HCID 178439928HCID 178439928, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Prepared analogously to Example 1d from methyl 4'-[[2-n-propyl-4-methyl-6-[2-cyano-3-(2-hydroxy-ethyl)-3-methylguanidino]-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate and 2N sodium hydroxide solution in ethanol.

Sources & evidence

ORD record
ord-06f3838de50043949d09f8a612c06f0d
Source dataset
uspto-grants-1996_05
Patent number
US05521177

Reaction notes

Loading…