化工社化工社 化学情報印刷レポート · 研究参考用
m-Chloroperbenzoic acid → N-(3-nitro-phenyl)-4-(N-oxido-3-pyridyl)-2-pyrimidine-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 反応物 | (3-Nitro-phenyl)-(4-pyridin-3-yl-pyrimidin-2-yl)-amine | HCID 9860872 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N-(3-nitro-phenyl)-4-(N-oxido-3-pyridyl)-2-pyrimidine-amine | HCID 22405644 | — |
反応手順
200 mg (0.68 mmol) of N-(3-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine-amine are suspended in 5 ml of methylene chloride, and 225 mg (0.71 mmol) of 3-chloroperbenzoic acid are added. After 2 hours a further 10 ml of methylene chloride are added. The suspension is stirred for a further 20 hours at room temperature. Filtration and flash chromatography of the residue (methylene chloride:methanol:25% aqueous ammonia solution=90:10:1) yield N-(3-nitro-phenyl)-4-(N-oxido-3-pyridyl)-2-pyrimidine-amine; Rf =0.4 (methylene chloride:methanol:25% aqueous ammonia solution=90: 10:1), m.p. 252°-258°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05521184 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-c3431567551c499387cdf45b4c7175ae |
| 出典メモ | uspto-grants-1996_05 |