反应详情

To a solution of 5.26 mL (40 mMol) 2-(2-chlorophenyl)ethanol and 8.36 mL (60 mMol) triethylamine in 100 mL tetrahydrofuran were added dropwise 3.25 mL (42 mMol) methanesulfonyl chloride with cooling. The reaction mixture was stirred 4 hours at ambient and was then concentrated under reduced pressure. The residue was partitioned between dichloromethane and water. The organic phase was separated and washed sequentially with water and saturated aqueous sodium chloride. The remaining organics were dried over sodium sulfate and concentrated under reduced pressure to give 9.22 gm (98.3%) of the title compound as a yellow oil. The product was used without further purification.

1. temperaturewith cooling
2. concentrationwas then concentrated under reduced pressure
3. customThe residue was partitioned between dichloromethane and water
4. customThe organic phase was separated
5. washwashed sequentially with water and saturated aqueous sodium chloride
6. dry with materialThe remaining organics were dried over sodium sulfate
7. concentrationconcentrated under reduced pressure