反应详情

A stirred solution of 50 grams (0.25 mole) of 3-(naphth-1-yl) propanoic acid and 20 drops (catalyst) of concentrated sulfuric acid in 250 mL of ethanol was heated at reflux for about 24 hours. After this time the reaction mixture was concentrated under reduced pressure to a residue. The residue was dissolved in diethyl ether, and the solution was washed with two 150 mL portions of an aqueous solution saturated with sodium bicarbonate and then with 150 mL of an aqueous solution saturated with sodium chloride. The organic layer was dried with magnesium sulfate and filtered. The filtrate was concentrated under reduced pressure, yielding 56.0 grams of ethyl 3-(naphth-1-yl)propanoate. The NMR spectrum was consistent with the proposed structure.

1. temperatureat reflux for about 24 hours
2. concentrationAfter this time the reaction mixture was concentrated under reduced pressure to a residue
3. dissolutionThe residue was dissolved in diethyl ether
4. washthe solution was washed with two 150 mL portions of an aqueous solution saturated with sodium bicarbonate
5. dry with materialThe organic layer was dried with magnesium sulfate
6. filtrationfiltered
7. concentrationThe filtrate was concentrated under reduced pressure