HuagongsheHuagongshe Chemistry Print Report · For research reference only
Selenium Dioxide → HCID 104763, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Selenium Dioxide | HCID 24007 | — |
| Reactant | Verrucarin A | HCID 6326658 | — |
| Product | HCID 104763 | HCID 104763 | — |
Reaction Steps
The trichothecene therapeutic agent 16-oxo verrucarin A is prepared by selenium dioxide oxidation of verrucarin A. The MAb hydrazide is then reacted with 16-oxo verrucarin A at 4C overnight with agitation, thereby yielding a unique Schiff base-linked targeting substance conjugate having the following structure: ##STR29##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05521290 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-3092c0105c134a139cfb8c1dfe03db83 |
| Source note | uspto-grants-1996_05 |