Methanesulfonyl chloride → N-(2-fluoro-5-nitrophenyl)methanesulfonamide

HRID 441120Notes

Reaction equation

[F:1][C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH2:4].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>>[F:1][C:2]1[CH:8]=[CH:7][C:6]([N+:9]([O-:11])=[O:10])=[CH:5][C:3]=1[NH:4][S:13]([CH3:12])(=[O:15])=[O:14]

Participants

Reactant 2

HCID 31297Methanesulfonyl chloride

HCID 677852-Fluoro-5-nitroaniline

Product 1

HCID 4416401N-(2-fluoro-5-nitrophenyl)methanesulfonamide

Procedure

First, the amino group of 2-fluoro-5-nitroaniline is sulfonylated by using methanesulfonyl chloride to give N-(2-fluoro-5-nitrophenyl)methanesulfonamide.

Sources & evidence

ORD record: ord-071c72fae2924dbd96f769897b455ca3
Source dataset: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05521311

Reaction notes

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