Dichloromethane → HCID 15337393, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-(4-(methanesulfonyl)phenyl)benzo[b]thiophene (1 g) from Step 2 in CH2Cl2 (70 mL) one equivalent of a 1M Br2 solution in CCl4 was added. The mixture was stirred at 25° C. for 2 hrs, then a 10% Na2S2O3 solution was added. After extraction with EtOAc, the organic layers were washed with a saturated solution of NaHCO3 (3×), brine, and dried over MgSO4, filtered and the solvent evaporated under vacuum. Purification by column chromatography using 5% EtOAc in toluene afforded the title compound.

Provenance & Evidence