反应详情

温度

0 °C

2-(4-Fluorophenyl)-3-(4-(methylthio)phenyl)-4H-thieno [2,3-c]furan-6-one (548 mg) (from Step 4) was dissolved in 10 mL of 10:1 CH2Cl2 /-MeOH and treated with 476 mg of MPPM at 0° C. After stirring for 15 min at 0° C. and 1.5 h at room temperature, the reaction mixture was quenched with 20 mL of sat. NaHCO3, and extracted with 50 ml of EtOAc. The extract was dried over MgSO4 and concentrated in vacuo. The residue was purified by silica gel chromatography eluted with EtOAc to give 490 mg of the title compound.

1. additiontreated with 476 mg of MPPM at 0° C
2. customthe reaction mixture was quenched with 20 mL of sat. NaHCO3
3. extractionextracted with 50 ml of EtOAc
4. dry with materialThe extract was dried over MgSO4
5. concentrationconcentrated in vacuo
6. customThe residue was purified by silica gel chromatography
7. washeluted with EtOAc