反应详情

To 3-bromomethyl-4-(4-(methylthio)phenyl)-5-phenyl-thiopene-2-carboxylic acid methyl ester (1 g, prepared by using the same procedure described for 3-bromomethyl-5-(fluorophenyl)-4-(4-(methylthio)phenyl)thiophene-2-carboxylic acid methyl ester of Example 8, Step 2 but substituting benzaldehyde for 4-fluorobenz-aldehyde) in DMSO (25 mL) in an ice bath was added powdered KCN. The mixture was stirred for 15 minutes at R.T., then H2O was added and the mixture was extracted with Et2O (2×), the organic layers were combined, washed with brine, dried over MgSO4, filtered and the solvent was evaporated under vacuum. Purification by silica gel chromatography afforded the title compound.

1. additionwas added
2. extractionthe mixture was extracted with Et2O (2×)
3. washwashed with brine
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customthe solvent was evaporated under vacuum
7. customPurification by silica gel chromatography