Trifluoroacetic acid → HCID 10392657, compound

Participants

Reaction Steps

To a solution of 2-[3-benzyloxycarbonylamino-6-(3-tert-butoxyphenyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (78 mg) in dry dichloromethane (3 mL) was added trifluoroacetic acid (57 mg). After 5 h the reaction was incomplete, and additional trifluoroacetic acid (57 mg) was added. After 18 h the reaction mixture was diluted with dichloromethane (50 mL), washed with water and brine, dried, and evaporated to a crude oil which was purified by chromatography, eluting with ethanol:ethyl acetate:dichloromethane (0.5:5:94.5), to give the title compound as a white solid (60 mg); TLC: Rf =0.15, ethanol:ethyl acetate:dichloromethane (0.5:5:94.5); HPLC: tR =6.04, FR=2.0, column A, water:acetonitrile (55:45); MS: m/z=546(M+1).

Provenance & Evidence