Phenylacetyl chloride → HCID 10438569, compound

HRID 441197Notes

Reaction equation

[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:40])[N:14]([CH2:26][C:27]([NH:29][CH:30]([CH:37]([CH3:39])[CH3:38])[C:31](=[O:36])[C:32]([F:35])([F:34])[F:33])=[O:28])[CH:15]=[C:16]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([OH:25])[CH:20]=2)[CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1([CH2:47][C:48](Cl)=[O:49])C=CC=CC=1>>[CH2:1]([O:8][C:9]([NH:11][C:12]1[C:13](=[O:40])[N:14]([CH2:26][C:27]([NH:29][CH:30]([CH:37]([CH3:38])[CH3:39])[C:31](=[O:36])[C:32]([F:35])([F:34])[F:33])=[O:28])[CH:15]=[C:16]([CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[C:21]([O:25][C:48](=[O:49])[CH3:47])[CH:20]=2)[CH:17]=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 10053504HCID 10053504, compound

Product 1

HCID 10438569HCID 10438569, compound

Procedure

2-[3-Benzyloxycarbonylamino-5-(3-hydroxybenzyl)-2-oxo-1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide was acylated using conditions similar to those described in Example 14.b., substituting acetic anhydride for phenylacetyl chloride, to give the title compound; NMR: 2.25 (s,3 and m,1), 6.95-7.41 (m,10); MS: m/z=602(M+1).

Sources & evidence

ORD record: ord-12ecedfab3f64ccc81844d8b88f01c17
Source dataset: uspto-grants-1996_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05521179

Reaction notes

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