Methyl iodide → HCID 22405461, compound

Participants

Reaction Steps

To a solution of 2-(3-trifluoroacetylamino-2-oxo-6-phenyl -1,2-dihydro-1-pyridyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide (Example 167 above) (200 mg)in dimethylformamide (2 mL) was added sodium carbonate (128 mg) and methyl iodide (130 μL). The mixture was stirred in a stoppered vessel overnight. Ethyl acetate and brine were added. The organic phase was separated, washed (brine), dried (MgSO4), and evaporated. Chromatography, eluting with dichloromethane:methanol (98:2), gave the title product (80 mg) as a white solid; TLC: Rf =0.15, dichloromethane:methanol (98:2); MS: m/z=506(M+1).

Provenance & Evidence