Ethyl Acetate → HCID 22071780, compound

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Reaction Steps

A mixture of 1-(6-chlorohexyl)-5-(4-nitrobenzoyl) -1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (675 mg) and potassium phthalimido (291 mg) in N,N-dimethylformamide (15 ml) was stirred at ambient temperature for 8 hours. The mixture was diluted with ethyl acetate and washed successively with 1N hydrochloric acid, aqueous sodium hydrogen carbonate and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo to give 5-(4-nitrobenzoyl)-1-(6-phthalimidohexyl) -1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (758 mg).

Provenance & Evidence