HCID 22405068, compound → HCID 22405038, compound

Participants

Reaction Steps

A solution of 1-(t-Butoxycarbonylmethyl)-4-{4-[2-(4methylphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoxalin -2-one (370 mg) in aqueous trifluoroacetic acid (15 ml) was stirred at ambient temperature for 2 hours and the solvent was evaporated in vacuo. The residue was dissolved in chloroform and the solution was washed with water and brine, and dried over magnesium sulfate. The solvent was evaporated in vacuo and the residue was purified by silica gel column (2% methanol in chloroform). The solvent was evaporated in vacuo and the residue was solidified with diethyl ether to give 1-carboxymethyl 4-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-1,2,3,4-tetrahydroquinoxalin-2-one (283 mg) as a white powder.

Provenance & Evidence