Ethyl Acetate → HCID 9873768, compound

Participants

Reaction Steps

To a solution of 1-carboxymethyl-5-{4-[2-(4 -methylphenyl)benzoylamino]benzoyl}-1,3,4,5-tetrahydro -1,5-benzodiazepin-2(2H)-one (90 mg), N-methylpiperazine (17 mg) and 1-hydroxybenzotriazole (27 mg) in N,N-dimethylformamide (4 ml) was added 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (39 mg) at ambient temperature and the mixture was stirred at the same temperature for 1.5 hours. The resulting mixture was diluted with ethyl acetate and then the solution was washed with saturated sodium bicarbonate aqueous solution and brine. Drying over magnesium sulfate, filtering and the removal of solvents afforded a crude product. The crude product was triturated with a mixture of diethyl ether and n-hexane (1:1) to give 5-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-1-[(4-methyl-1-piperazinyl)carbonylmethyl]-1,3,4,5-tetrahydro-1,5-benzodiazepin-2(2H)-one (100 mg) as a white powder.

Provenance & Evidence