Sodium Iodide → HCID 22405074, compound

Participants

Reaction Steps

A solution of 5-(4-[2-(4-methylphenyl)benzoylamino]-benzoyl}-1,3,4,5-tetrahydro-1,5-benzodiazepine-2(2H)thione (460 mg), 3-dimethylaminopropyl chloride hydrochloride (740 mg), potassium carbonate (1.29 g) and sodium iodide (catalytic amount) in acetone (40 ml) was stirred for 19 hours at 60° C. The mixture was filtered and the filtrate was evaporated. The residue was purified by column chromatography (SiO2 30 g, 5% methanol in chloroform) to give 2-[3-(dimethylamino)propylthio]-5-{4-[2-(4-methylphenyl)benzoylamino]benzoyl}-4,5-dihydro-3H-1,5benzodiazepine (200 mg).

Provenance & Evidence