反应详情

温度

130 °C

A mixture of 33 g of m-nitro-acetylacetanilide, 38.1 g of methyl orthoformate and 13 drops of 36° Be sulfuric acid was allowed to stand for 16 hours and after the addition of 40 drops of quinoline and 150 ml of toluene, the mixture was heated to 130° C. while distilling of the methanol formed as an azeotrope. The mixture was cooled and vacuum filtered and the recovered precipitate was crystallized from acetone to obtain 24 g of m-nitro-3-methoxy-crotonanilide melting at 187° C.

1. distillationwhile distilling of the methanol
2. customformed as an azeotrope
3. temperatureThe mixture was cooled
4. filtrationvacuum filtered
5. customthe recovered precipitate was crystallized from acetone