HRID44128

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID6251

未命名化合物

结构：CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C

HCID148124

Docetaxel

C43H53NO14

结构：O.O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID22814120

Dextrose monohydrate

C6H14O7

PRODUCTS

生成物

结构：CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@@]1(C)C(=O)[C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c4ccccc4)C[C@@](O)([C@@H](OC(=O)c4ccccc4)[C@H]21)C3(C)C.OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

HCID86641782

未命名化合物

PROCEDURE

实验过程

An aliquot of the mannitol solution was added to the vessel containing the docetaxel solution, which was then re-sealed and mixed until homogeneous (about 15 minutes) at about 600-800 RPM. The mixed solution was then filtered, and a number of pre-sterilized lyophilization vials were aseptically filled with the filtered solution. The vials were immediately transferred to a freeze-dryer and lyophilized under vacuum using nitrogen. A lyophilizate was obtained, and used to reconstitute clear solutions with the sucrose fatty acid ester diluent. The clear solution was further diluted for administrative purposes in saline and D5W. Stability measurements indicated that the solutions remained clear and non-precipitated after 24 hours.

WORKUP

后处理

customwas then re-sealed
additionmixed until homogeneous (about 15 minutes) at about 600-800 RPM
filtrationThe mixed solution was then filtered
additiona number of pre-sterilized lyophilization vials were aseptically filled with the filtered solution
customA lyophilizate was obtained

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0581785b1df846d9a5c06ef2f4827f09
来源数据集: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08541360B2
来源说明: uspto-grants-2013_09

反应 SMILES

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