Ethanol → HCID 135996309, compound

Participants

Reaction Steps

4-Amino-5-nitroso-2-(2-propoxy-5-t-butylthiophenyl)-pyrimid-6-one (6.5 g.) (see Reference Example 7) was dissolved in boiling ethanol (150 ml.), and the solution was added all at once to a solution of sodium dithionite (26 g.) in water (150 ml.) at 80° C. The mixture immediately turned yellow. After 2 minutes, the mixture was cooled to room temperature and diluted with water (700 ml.), and then it was left to stand in an ice bath for 1 hour. The solid formed [4,5-diamino-2-(2-propoxy-5-t-butylthiophenyl)-pyrimid-6-one] was filtered off and washed with water. This material was used immediately for the next stage of the synthesis, because darkening occurred on standing.

Provenance & Evidence