Hydrochloric Acid → 24NH2PYRIMDN,5(3MEAM4MEO5DIMEAM)BNZYL

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Reaction Steps

4.0 G. of 5'-[(2,4-diamino-5-pyrimidinyl)methyl]3'-dimethylamino-2'-methoxy-N-methylacetanilide (prepared as described in the first paragraph of Example 2) and 100 ml. of 1-N hydrochloric acid were boiled under reflux for 2 hours. After neutralization and evaporation in vacuo, purification of the residue over silica gel with methylene chloride/propanol (8:2) and recrystallization from ethanol, there was obtained 2,4-diamino-5-[3-dimethylamino-4-methoxy-5-(methylamino)benzyl]pyrimidine, having a melting point of 183° C.

Provenance & Evidence