HCID 20324276, compound → HCID 20324250, compound

HRID 441355Notes

Reaction equation

HRID 441355 reaction equation
[Cl:1][C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[C:4]([C:12]#[CH:13])([OH:11])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>[Pd]>[Cl:1][C:2]1[CH:17]=[C:16]([Cl:18])[CH:15]=[CH:14][C:3]=1[C:4]([CH2:12][CH3:13])([OH:11])[C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1

Participants

3

Reactant 1

HCID 20324276HCID 20324276, compound

Product 1

HCID 20324250HCID 20324250, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

0.48 g. of 10% palladium-on-carbon catalyst are added to a solution of 19.4 g. of 2,4-dichloro-α-ethynyl-benzhydrol in 200 ml. of benzene, and the mixture is hydrogenated until the absorption of the calculated amount of hydrogen (about 60 minutes). Thereafter the catalyst is removed by filtration, and the solvent is evaporated. The obtained 16.1 g. of crude product is distilled in vacuo, to yield pure 2,4-di-chloro-α-ethyl-benzhydrol, b.p.: 136°-138° C./0.1 mmHg.

Workup

  1. customof benzene, and the mixture is hydrogenated until the absorption of the calculated amount of hydrogen (about 60 minutes)
  2. customThereafter the catalyst is removed by filtration
  3. customthe solvent is evaporated
  4. distillationof crude product is distilled in vacuo

Sources & evidence

ORD record
ord-24d863119fb142a9a5d3e685be2b5efc
Source dataset
uspto-grants-1977_08
Patent number
US04039589

Reaction notes

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