反应详情

4-Dodecylacetanilide (252 g) was added portionwise over 45 minutes to a stirred solution of nitric acid (density 1.50 g. ml.) (210 ml) and water (23 ml) keeping the temperature between 35° and 40° C. The mixture was stirred for a further 30 minutes, drowned into cold water (1200 ml) and the precipitated solid filtered off, washed acid free with water, dried and recrystallised from ethanol to give 202 g of 2-nitro-4-dodecylacetanilide as fine needles, melting at 71°-2° C.

1. customthe temperature between 35° and 40° C
2. filtrationthe precipitated solid filtered off
3. washwashed acid free with water
4. customdried
5. customrecrystallised from ethanol