反应详情

A solution of methyl iodide (130 g) in acetone (160 ml) was added to a stirred mixture of 2-nitro-4-dodecylacetanilide (196 g) and sodium hydroxide (130 g) in acetone (1100 ml) at room temperature. The mixture was heated rapidly and allowed to boil for 8 minutes, filtered hot and the filtrate evaporated to a semi-solid which was partitioned between toluene (800 ml) and water (400 ml). The organic layer was washed with water, dried and evaporated to give 199 g of 2-nitro-4-dodecyl-N-methylacetanilide as a dark oil.

1. temperatureThe mixture was heated rapidly
2. filtrationfiltered hot
3. customthe filtrate evaporated to a semi-solid which
4. customwas partitioned between toluene (800 ml) and water (400 ml)
5. washThe organic layer was washed with water
6. customdried
7. customevaporated