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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 441385Generated: October 30, 2026

Hydrazine hydrate (1:1) → 1-[(aminooxy)methyl]-8-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine

https://huagongshe.com/reaction/441385

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrazine hydrate (1:1)HCID 24654—
Reactant8-bromo-1-[(phthalimidooxy)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 20361184—
SolventEthanolHCID 702—
Product1-[(aminooxy)methyl]-8-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepineHCID 20361225—

Reaction Steps

In the manner given in Example 2, a solution of hydrazine hydrate in ethanol is treated at 65° C. with 8-bromo-1-[(phthalimidooxy)methyl]-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine to give 1-[(aminooxy)methyl]-8-bromo-6-(2-pyridyl)-4H-s-triazolo[4,3-a][1,4]benzodiazepine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04039551
Source datasetuspto-grants-1977_08
ORD IDord-2aabb79b476a49008ff10c7c7e6190c0
Source noteuspto-grants-1977_08