HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Dimethylhydroxylamine | HCID 27970 | — |
| Reactant | 8-(methylthio)-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 20361160 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine | HCID 12612377 | — |
Reaction Steps
In the manner given in Example 15, 8-methylthio-1-(chloromethyl)-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine is treated with a cold mixture of N,N-dimethylhydroxylamine and sodium hydride in dimethylformamide to give 8-methylthio-1-[(dimethylamino)methyl]-6-phenyl-4H-s-triazolo [4,3-a][1,4]benzodiazepine, N1 -oxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04039551 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-ef8e1732310649b08f77481c8bf1d5a6 |
| Source note | uspto-grants-1977_08 |