HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethylhydroxylamine → 8-bromo-1-[(diethylamino)methyl]-6-(2-pyridyl)-4H-s-triazolo [4,3-a][1,4]benzodiazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethylhydroxylamine | HCID 19463 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s triazolo[4,3-a][1,4]benzodiazepine | HCID 20361200 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 8-bromo-1-[(diethylamino)methyl]-6-(2-pyridyl)-4H-s-triazolo [4,3-a][1,4]benzodiazepine | HCID 20361224 | — |
Reaction Steps
In the manner given in Example 15, 8-bromo-1-(chloromethyl)-6-(2-pyridyl)-4H-s-triazolo[4,3-a] [1,4]-benzodiazepine is treated with a cold mixture of N,N-diethylhydroxylamine and sodium hydride in dimethylformamide to give 8-bromo-1-[(diethylamino)methyl]-6-(2-pyridyl)-4H-s-triazolo [4,3-a][1,4]benzodiazepine, N1 -oxide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04039551 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-85ba27c0cbbd439fbadebcfd689b5bd6 |
| Source note | uspto-grants-1977_08 |