HCID 21421182, compound → HCID 21421206, compound

HRID 441413Notes

Reaction equation

HRID 441413 reaction equation
[N+:1]([C:4]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:5]=1[O:6][CH2:7][CH:8]([OH:15])[CH2:9][NH:10][C:11]([CH3:14])([CH3:13])[CH3:12])([O-])=O>CO.[Ni]>[ClH:20].[ClH:20].[NH2:1][C:4]1[CH:19]=[C:18]([Cl:20])[CH:17]=[CH:16][C:5]=1[O:6][CH2:7][CH:8]([OH:15])[CH2:9][NH:10][C:11]([CH3:14])([CH3:13])[CH3:12]

Participants

4

Reactant 1

HCID 21421182HCID 21421182, compound

Product 1

HCID 21421206HCID 21421206, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

1-(2-nitro-4-chlorophenoxy)-2-hydroxy-3-tert.-butylamino propane was hydrogenated in the presence of Raney-nickel in methanol to obtain 1-(2-amino-4-chloro-phenoxy)-2-hydroxy-3-tert.-butylamino propane dihydrochloride having a melting point of 260°-262° C.

Sources & evidence

ORD record
ord-eacfb01125bc41cc9c5e4bff4d29c1e9
Source dataset
uspto-grants-1977_08
Patent number
US04039685

Reaction notes

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