HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 4-(4-Hydroxy-4-phenylpiperidin-1-yl)butan-2-one--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Nitromethane | HCID 6375 | — |
| Reactant | 4-Phenylpiperidin-4-ol hydrochloride | HCID 18614383 | — |
| Solvent | Cyclohexane | HCID 8078 | — |
| Product | 4-(4-Hydroxy-4-phenylpiperidin-1-yl)butan-2-one--hydrogen chloride (1/1) | HCID 21332006 | — |
Reaction Steps
The starting material is prepared as follows: The solution of 20 g of 4-hydroxy-4-phenylpiperidine hydrochloride, 10 ml of acetone, 5.6 g of paraformaldehyde and 100 ml of nitromethane is refluxed for 12 hours. It is diluted with 500 ml of cyclohexane and the precipitate collected, to yield the 4-(4-hydroxy-4-phenylpiperidino)-2-butanone hydrochloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04039676 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-df87cce5a82a49759a684c7aec64b8b1 |
| Source note | uspto-grants-1977_08 |