Ethanol → Ethyl 4-(2-nitrophenyl)-3-oxobutanoate

Participants

Reaction Steps

30 gm (0.103M) ethyl-o-nitrophenylacetylacetoacetate was added over a period of 15-20 minutes to a saturated ammoniacal ethanol solution (prepared by bubbling NH3 gas into 400 cc. absolute alcohol for 15- 20 minutes while cooling the solution to 0- 5° C.). The orangy mixture was stirred for 1 hour at 5°- 10° C. and then left in the refrigerator overnight. The ethyl-γ-2-nitrophenylacetoacetate crystals formed were filtered and dried in vacuum. Additional solid was obtained after evaporation of the filtrate and washing with water to remove any amide formed.

Provenance & Evidence