HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(2-nitrophenyl)-3-oxobutanoate → Ethyl 2-(1H-indol-2-yl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(2-nitrophenyl)-3-oxobutanoate | HCID 10857922 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | Ethyl 2-(1H-indol-2-yl)acetate | HCID 11106442 | — |
Reaction Steps
A sample of 12.0 gm (0.048M) of ethyl-γ-2-nitrophenylacetoacetate was dissolved in 200 cc. glacial acetic acid. Approximately 21/2 spatulas of 5% Pd/C was added to the solution and the compound was reduced on the Parr hydrogenator. Ethyl-2-indolylacetate was obtained as a dark orangy oily liquid after removal of catalyst and solvent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04040832 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-156003c0cf24440b926e190e9cdcd425 |
| Source note | uspto-grants-1977_08 |