反应详情

A solution of trans 3-bromocinnamoyl chloride (12.3 g) in anhydrous toulene (150 ml) was added slowly with stirring to a solution of ethylamine (10 g) in dry ether (100 ml) at room temperature. The reaction mixture was heated at reflux for 1 hour, and the solvent and excess amine were then removed under reduced pressure. The residue was triturated with water, filtered, and recrystallized from ethanol-water to give trans 3-bromo-N-ethylcinnamamide, m.p. 89°-90° C., as a white crystalline material. NMR and IR spectra as well as elemental analysis were consistent with the assigned structure.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 1 hour
3. customthe solvent and excess amine were then removed under reduced pressure
4. customThe residue was triturated with water
5. filtrationfiltered
6. customrecrystallized from ethanol-water