Hydrochloric Acid → 4-Amino-1,2,3,4-tetrahydronaphthalen-1-one hydrochloride

Participants

Reaction Steps

A solution of 19.6 g of N-(1,2,3,4-tetrahydro-4-oxo-1-naphthyl)formamide in 214 ml of 95% ethanol and 214 ml of 2N hydrochloric acid is heated at reflux for 3 hours and then stirred at room temperature for 2 days. The solution is filtered and the filtrate concentrated in vacuo to afford a dark residue. The residue is dried using ethanol to remove water in vacuo and this procedure affords 20.2 g of the title compound, melting point 200° C. to 216° C. (dec.).

Provenance & Evidence