Diethyl Ether → HCID 178488833, compound

HRID 441596Notes

Reaction equation

HRID 441596 reaction equation
[N:1]#[N:2].[CH3:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[C:10]2[S:15]([NH:18][C@H:19]([C:27]([OH:29])=O)[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:26])[NH2:25])(=[O:17])=[O:16].C(OCC)C.S(Cl)([Cl:37])=O>>[N:1]#[N:2].[ClH:37].[CH3:3][O:4][C:5]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:6]=1[CH:7]=[CH:8][CH:9]=[C:10]2[S:15]([NH:18][C@H:19]([C:27]([Cl:37])=[O:29])[CH2:20][CH2:21][CH2:22][NH:23][C:24](=[NH:26])[NH2:25])(=[O:17])=[O:16]

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 24386Thionyl ChlorideHCID 178488834HCID 178488834, compound

Product 1

HCID 178488833HCID 178488833, compound

Procedure

A suspension of 2.00 g of N2 -(5-methoxy-1-naphthalenesulfonyl)-L-arginine in 20 ml of thionyl chloride was stirred for 2 hours at room temperature. Addition of cold dry diethyl ether resulted in a precipitate which was collected by filtration and washed several times with dry diethyl ether to give N2 -(5-methoxy-1-naphthalenesulfonyl)-L-arginyl chloride hydrochloride.

Workup

  1. customresulted in a precipitate which
  2. filtrationwas collected by filtration
  3. washwashed several times with dry diethyl ether

Sources & evidence

ORD record
ord-13239ceb7ba04ba5b31c992e32976813
Source dataset
uspto-grants-1977_08
Patent number
US04041156

Reaction notes

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