HuagongsheHuagongshe Chemistry Print Report · For research reference only
L-Pyroglutamic Acid → HCID 86734994, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | L-Pyroglutamic Acid | HCID 7405 | — |
| Reactant | Methylamphotericin B | HCID 11968030 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86734994 | HCID 86734994 | — |
Reaction Steps
Amphotericin B methyl ester (9.36 g, 0.01 Mol) is added in portions to a solution of pyroglutamic acid (1.30 g, 0.01 Mol) in 500 ml of water and stirred until dissolution (5-10 minutes). The clear solution is thereafter lyopholized. The resulting product is found to be very soluble in water (more than 10% soluble at RT).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04041232 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-223ddf562a1e47b18aef8bded791f322 |
| Source note | uspto-grants-1977_08 |