Piperidine-1-propanol → HCID 86733061, compound

HRID 441629Notes

Reaction equation

HRID 441629 reaction equation
[CH:1]1[C:9]2[C:8]3[CH:10]=[C:11]([C:14]([Cl:16])=[O:15])[CH:12]=[CH:13][C:7]=3[O:6][C:5]=2[CH:4]=[CH:3][C:2]=1[C:17](Cl)=[O:18].[N:20]1([CH2:26][CH2:27][CH2:28][OH:29])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1>C(Cl)(Cl)Cl>[OH2:6].[ClH:16].[ClH:16].[N:20]1([CH2:26][CH2:27][CH2:28][O:29][C:17]([C:2]2[CH:3]=[CH:4][C:5]3[O:6][C:7]4[CH:13]=[CH:12][C:11]([C:14]([O:29][CH2:28][CH2:27][CH2:26][N:20]5[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]5)=[O:15])=[CH:10][C:8]=4[C:9]=3[CH:1]=2)=[O:18])[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1

Participants

4

Reactant 2

HCID 66032Piperidine-1-propanolHCID 12331791HCID 12331791, compound

Product 1

HCID 86733061HCID 86733061, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

A solution of 12.8 g (0.044 mole) of dibenzofuran-2,8-dicarbonyl chloride and 12.6 g (0.088 mole) of 3-piperidinopropanol in 1 liter of chloroform is refluxed for 4 hours. Upon dilution with diethyl ether, the product is collected and crystallized from ethanol, to give bis(3-piperidinopropyl)dibenzofuran-2,8-dicarboxylate dihydrochloride monohydrate, M.P. 252°-253° C.

Workup

  1. customUpon dilution with diethyl ether, the product is collected
  2. customcrystallized from ethanol

Sources & evidence

ORD record
ord-ab347cf037084b2fa220a7777835b3ca
Source dataset
uspto-grants-1977_08
Patent number
US04041165

Reaction notes

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