HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 178522702, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-Oxo-4H-9-thia-1,4a-diaza-fluorene-3-carboxylic acid | HCID 2725859 | — |
| Reactant | HCID 178509299 | HCID 178509299 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178522702 | HCID 178522702 | — |
Reaction Steps
To a solution of 360 mg. of 1,1'-carbonyldiimidazole in 6 ml. of dry tetrahydrofuran at 140° C. is added dropwise 500 mg. of 3-carboxy-4-oxo-4H-pyrimido[2,1-b]benzothiazole in 6 ml. of dry dimethylformamide. After heating for 3 hrs., 186 mg. of 5-aminotetrazole is added, and the heating maintained for an additional 15 min. The reaction mixture is cooled and the precipitated product filtered. Recrystallization from dimethylformamide gives 200 mg. of the desired product, m.p. 330°-332° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04041163 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-9b67cc2e5eab4594876235a38dfa0c43 |
| Source note | uspto-grants-1977_08 |