Water → HCID 178507374, compound

Participants

Reaction Steps

To a suspension of 4.5 g. of N-(5-tetrazolyl)-7-nitro-4-oxo-4H-pyrimido[2,1-b]benzothiazole-3-carboxamide in 50 ml. of water and 25 ml. of dimethylformamide is added sufficient 1N aqueous sodium hydroxide to effect a solution. Platinum oxide (300 mg.) is added and the suspension shaken in a hydrogen atmosphere at an initial pressure of 30 p.s.i. When the theoretical amount of hydrogen is absorbed the spent catalyst is filtered and the filtrate treated with sufficient 6N hydrochloric acid to register acid to Congo red paper. The acidified filtrate is further diluted with 25 ml. of water and cooled in an ice bath. The desired product is filtered and recrystallized from dimethylformamide.

Provenance & Evidence