Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Methyl Chloride | HCID 6327 | — |
| Reactant | Tetrahydropyrimidine-2-thione | HCID 2723785 | — |
| Reactant | 1,4,5,6-Tetrahydropyrimidin-2-ylhydrazine hydrochloride | HCID 21417040 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Hydrazine | HCID 9321 | — |
| Product | 2-Methylthio-1,4,5,6-tetrahydropyrimidine hydrochloride | HCID 21417132 | — |
Reaction Steps
The preparation of the starting material, 1,4,5,6-tetrahydropyrimidin-2-ylhydrazine hydrochloride, is carried out as follows: 1,4,5,6-tetrahydropyrimidin-2-thione and methyl chloride (excess) are added to isopropanol and the mixture heated in an autoclave at 170°-180° C. for hours. Cooling to 4° C. yields a precipitate of 2-methylthio-1,4,5,6-tetrahydropyrimidine hydrochloride, which upon treatment with hydrazine in boiling ethanol yields the desired intermediate melting at 191°-192° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | USRE029358 |
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| Source dataset | uspto-grants-1977_08 |
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| ORD ID | ord-ad75af06ea2e46a3a06638c3d8f3065b |
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| Source note | uspto-grants-1977_08 |
|---|
