Sodium Hydroxide → (4-Chloro-2-fluorophenyl)hydrazine

HRID 441695Notes

Reaction equation

HRID 441695 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[C:5]([F:11])[CH:4]=1.[OH-].[Na+]>C(Cl)Cl>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][NH2:10])=[C:5]([F:11])[CH:4]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 2782933(4-Chloro-2-fluorophenyl)hydrazine hydrochloride

Product 1

HCID 2782934(4-Chloro-2-fluorophenyl)hydrazine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Six parts of 4-chloro-2-fluorophenyl hydrazine hydrochloride was shaken with 100 parts of methylene chloride and 100 parts of 1-molar aqueous sodium hydroxide for one to two minutes until a clear two-phase solution was obtained. The organic phase was washed three times with 60 parts of water, dried with anhydrous magnesium sulfate, and evaporated under a reduced pressure of 50 to 300 mm Hg. to give 3.8 parts of pale tan 4-chloro-2-fluorophenyl hydrazine, m.p. 57°-63° C.

Workup

  1. customwas obtained
  2. washThe organic phase was washed three times with 60 parts of water
  3. dry with materialdried with anhydrous magnesium sulfate
  4. customevaporated under a reduced pressure of 50 to 300 mm Hg

Sources & evidence

ORD record
ord-625800958ea74db08cdec9ac182efd25
Source dataset
uspto-grants-1977_08
Patent number
US04042373

Reaction notes

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