Methyl iodide → HCID 20359916, Verbindung

HRID 441716Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 441716
[OH:1][N:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[N:4]=[C:3]1[C:12]([F:15])([F:14])[F:13].CI.[C:18](=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH3:18][O:1][N:2]1[C:10]2[C:5](=[N:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[N:4]=[C:3]1[C:12]([F:15])([F:14])[F:13]

Komponenten

5

Edukt 3

HCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 30824181-Hydroxyfluromidine

Produkt 1

HCID 20359916HCID 20359916, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

1-Hydroxy-6-chloro-2-(trifluoromethyl)-1H-imidazo-(4,5-b)pyridine (5 grams), 80 milliliters of acetone, 5 milliliters of methyl iodide, and 10 grams of anhydrous potassium carbonate were mixed, heated and refluxed with stirring for twelve hours. The reaction mixture was then filtered, evaporated and eluted off of a silica column with diethyl ether, yielding the desired 1-methoxy-6-chloro-2-(trifluoromethyl)-1H-imidazo(4,5-b)pyridine product. It was recrystallized from petroleum ether (boiling at 60°-80° C.). The product so obtained melted at 91°-2° C.

Aufarbeitung

  1. temperatureheated
  2. temperaturerefluxed
  3. filtrationThe reaction mixture was then filtered
  4. customevaporated
  5. washeluted off of a silica column with diethyl ether

Quellen und Nachweise

ORD-Eintrag
ord-5bdeb192bb2746629d7bf2e3b93e1f97
Quelldatensatz
uspto-grants-1977_08
Patentnummer
US04042593

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