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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 441730Generated: October 30, 2026

Phosphorus oxychloride → 3-Chloro-2,5-dimethylpyrazine

https://huagongshe.com/reaction/441730

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPhosphorus oxychlorideHCID 24813—
ReactantHCID 178430529HCID 178430529—
Product3-Chloro-2,5-dimethylpyrazineHCID 66771—

Reaction Steps

The 2-hydroxy-3,6-dimethylpyrazine disclosed by Baxter et al can be reacted with phosphorus oxychloride by the method described in Preparation 13, Step B, to provide 2-chloro-3,6-dimethylpyrazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04042586
Source datasetuspto-grants-1977_08
ORD IDord-f2b2b90324b940378497c7d6eed0dfa0
Source noteuspto-grants-1977_08