HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 3,5-Dimethoxypyrazin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-Amino-5-bromo-3-methoxypyrazine | HCID 11344724 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3,5-Dimethoxypyrazin-2-amine | HCID 20528923 | — |
Reaction Steps
A mixture of 0.1 mole of 2-amino-3-methoxy-5-bromopyrazine and 0.1 mole of sodium in 160 ml. of anhydrous methanol is refluxed 5- 10 hours and poured into water. The product is extracted with ether or chloroform and recrystallized from a suitable solvent such as ethanol to give 2-amino-3,5-dimethoxypyrazine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04042586 |
| Source dataset | uspto-grants-1977_08 |
| ORD ID | ord-024e6e3d54ee4671aad9a28434ba94e4 |
| Source note | uspto-grants-1977_08 |