Acetic Acid → HCID 20323915, compound

Participants

Reaction Steps

To a solution of 0.5 g of metallic sodium in 50 ml of anhydrous ethanol was added a solution of 3.0 g of ethyl 2-hydroxy-3-(3-benzoylphenyl)-3-butenoate in 20 ml of anhydrous ethanol. The resulting mixture was refluxed for 20 minutes and then cooled. The reaction liquid was charged with 5 ml of glacial acetic acid, and the ethanol was removed therefrom by distillation at a low temperature and under reduced pressure. The residue was charged with ethyl acetate and water, thereby effecting ethyl acetate extraction. The ethyl acetate layer was successively washed with water, aqueous sodium bicarbonate solution and water, and then dried over anhydrous magnesium sulfate. Thereafter, the ethyl acetate was removed by distillation under reduced pressure to obtain 2.2 g of ethyl 3-methyl-3-(3-benzoylphenyl)-pyruvate. The yield was 73%.

Provenance & Evidence