(p-Chlorophenyl)trmethylsilane → HCID 21417831, compound

Participants

Reaction Steps

4-Methylamino-4'-trimethylsilylbenzhydrol was prepared by a Grignard reagent formulated from 0.2 mole of 4-trimethylsilylchlorobenzene and 0.2 mole of magnesium with 0.2 mole of N-methylaminobenzaldehyde. 0.4 mole of the thus obtained 4-methylamino-4'-trimethylsilylbenzhydrol was dissolved in pyridine, and to the resultant solution was added, dropwise over a period of 40 hours at room temperature, an oxidizing agent prepared by adding 125 ml of pyridine to a solution of 7.5 ml of water and 12.5 mole of chromic anhydride under agitation while being cooled with water. The reaction product was refined by chromatography using silica gel, to obtain 41 g of 4-methylamino-4'-trimethylsilyl benzophenone in a yield of 38%.

Provenance & Evidence