HCID 21418195, compound → HCID 21418222, compound

Participants

Reaction Steps

6-Ethoxyisoquinoline (0.5 g.) and ethyl (2-bromoethyl) carbamate (0.7 g.) in acetonitrile (20 ml) were heated under reflux for 50 hrs. The solvent was removed in vacuo and the residue triturated with ethyl acetate to give 2-(2-carbethoxyaminoethyl)-6-ethoxyisoquinolinium bromide (1.0 g.). The crude bromide was heated under reflux in 24% aqueous hydrobromic acid (16 ml) for 2 hrs. The solvent was removed in vacuo and the residue was crystallised from ethanol and had m.p. 238°-240° (dec.).

Provenance & Evidence